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Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.

Abstract：

:Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are described.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Högberg M,Engelhardt P,Vrang L,Zhang H

doi

10.1016/s0960-894x(99)00675-7

subject

Has Abstract

pub_date

2000-02-07 00:00:00

pages

265-8

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00675-7

journal_volume

10

pub_type

杂志文章

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