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Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates.

Abstract：

:Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Fang W,Cai Y,Chen X,Su R,Chen T,Xia N,Li L,Yang Q,Han J,Han S

doi

10.1016/j.bmcl.2009.02.059

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1903-7

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00217-0

journal_volume

19

pub_type

杂志文章

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