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Diamine preparation for synthesis of a water soluble Ni(II) salen complex.

Abstract：

:A reliable and efficient synthesis of a Ni(II) salen complex useful in probing nucleic acid structure is described and illustrates a general approach for constructing cis diamines suitable for assembly into N2O2 Schiff base complexes. Two equivalents of an aryllithium reacted with 1,4-dimethylpiperazine-2,3-dione to form the symmetric alpha-dione. This material was then converted to its dioxime and reduced by TiCl4/NaBH4 to yield the meso-diamine. Condensation of the diamine and salicyladehyde, coordination of nickel and final methylation generated the desired water soluble and redox active complex.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shearer JM,Rokita SE

doi

10.1016/s0960-894x(99)00020-7

subject

Has Abstract

pub_date

1999-02-08 00:00:00

pages

501-4

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960894X99000207

journal_volume

9

pub_type

杂志文章

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