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Synthesis and the hepatoprotective activity of dibenzocyclooctadiene lignan derivatives.

Abstract：

:The halogenated and oxidized derivatives (1a-1e, 1a'-1c', 2a-2d, 2a'-2b', 3a-3e, 3' and 3a'-3b') of schizandrin (1), schizandrin B (2) and schisanhenol (3) were synthesized. The hepatoprotective effects of these dibenzocyclooctadiene lignan analogues against CCl4-induced injury were preliminarily evaluated. Most of the analogues exhibited higher protective effects than the positive control biphenyldicarboxylate (DDB). Among these active analogues, dichloroschisanhenol (3a) exhibited the strongest protective activity (cell survival rate exceeding 98.0%).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

He T,Wang QY,Shi JZ,Fan TY,Yan C,Huang LJ,Liu S,Hao XJ,Mu SZ

doi

10.1016/j.bmcl.2014.02.020

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

1808-11

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00143-7

journal_volume

24

pub_type

杂志文章

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