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Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.

Abstract：

:A series of pyrazinones were prepared and evaluated as potential CRF(1)R PET imaging agents. Optimization of their CRF(1)R binding potencies and octanol-phosphate buffer phase distribution coefficients are discussed herein.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Denhart DJ,Zuev D,Ditta JL,Hartz RA,Ahuja VT,Mattson RJ,Huang H,Mattson GK,Zueva L,Nielsen JM,Kozlowski ES,Lodge NJ,Bronson JJ,Macor JE

doi

10.1016/j.bmcl.2013.02.009

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

2052-5

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00183-2

journal_volume

23

pub_type

杂志文章

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