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Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

Abstract：

:Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Gwaltney SL 2nd,Imade HM,Barr KJ,Li Q,Gehrke L,Credo RB,Warner RB,Lee JY,Kovar P,Wang J,Nukkala MA,Zielinski NA,Frost D,Ng SC,Sham HL

doi

10.1016/s0960-894x(01)00098-1

subject

Has Abstract

pub_date

2001-04-09 00:00:00

pages

871-4

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960894X01000981

journal_volume

11

pub_type

杂志文章

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