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Novel bis(indolyl)hydrazide-hydrazones as potent cytotoxic agents.

Abstract：

:A series of bis(indolyl) hydrazide-hydrazones 5a-n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a-n in good yields. Among the synthesized bis(indolyl)hydrazide-hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found to be the most potent against multiple cancer cell lines (IC(50)=1.0 μM, MDA-MB-231). The compound 5k exhibited selective cytotoxicity against breast cancer cell line MCF7 (IC(50)=3.1 μM).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kumar D,Maruthi Kumar N,Ghosh S,Shah K

doi

10.1016/j.bmcl.2011.11.031

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

212-5

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01572-1

journal_volume

22

pub_type

杂志文章

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