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Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors.

Abstract：

:A highly practicable synthesis of both enantiomers of 3-hydroxypipecolic acid derivatives 1, 2, 3, 4 is described. Screening of these molecules for glycosidase inhibition has been examined. Compound 3 was shown to be a potent inhibitor of beta-N-acetylglucosaminidase as well as Escherichia coli beta-glucuronidase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ohara C,Takahashi R,Miyagawa T,Yoshimura Y,Kato A,Adachi I,Takahata H

doi

10.1016/j.bmcl.2008.02.028

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

1810-3

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00210-2

journal_volume

18

pub_type

杂志文章

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