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Fluorometric detection of adenine in target DNA by exciplex formation with fluorescent 8-arylethynylated deoxyguanosine.

Abstract：

:We demonstrated an intriguing method to discriminate adenine by incident appearance of an intense new emission via exciplex formation in hybridization of target DNA with newly designed fluorescent 8-arylethynylated deoxyguanosine derivatives. We described the synthesis of such highly electron donating fluorescent guanosine derivatives and their incorporation into DNA oligomers which may be used for the structural study and the fluorometric analysis of nucleic acids.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Saito Y,Kugenuma K,Tanaka M,Suzuki A,Saito I

doi

10.1016/j.bmcl.2012.04.011

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

3723-6

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00450-7

journal_volume

22

pub_type

杂志文章

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