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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.

Abstract：

:The synthesis, structure-activity relationship and modeling of a series of 5-substituted-N-aryl pyridazinone based p38alpha inhibitors are described. In comparing the series to the similar N-aryl pyridinone series, it was found that the pyridazinones maintained a weaker interaction to the p38 enzyme, and therefore showed generally weaker binding than the pyridinones.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jerome KD,Hepperle ME,Walker JK,Xing L,Devraj RV,Benson AG,Baldus JE,Selness SR

doi

10.1016/j.bmcl.2010.03.088

subject

Has Abstract

pub_date

2010-05-15 00:00:00

pages

3146-9

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00429-4

journal_volume

20

pub_type

杂志文章

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