Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

Abstract:

:The structure activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1'-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.

journal_name

Bioorg Med Chem Lett

authors

Lee J,Kang SU,Kim SY,Kim SE,Kang MK,Jo YJ,Kim S

doi

10.1016/s0960-894x(01)00095-6

subject

Has Abstract

pub_date

2001-04-23 00:00:00

pages

961-4

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(01)00095-6

journal_volume

11

pub_type

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