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New chemotypes for cathepsin K inhibitors.

Abstract：

:Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Teno N,Irie O,Miyake T,Gohda K,Horiuchi M,Tada S,Nonomura K,Kometani M,Iwasaki G,Betschart C

doi

10.1016/j.bmcl.2008.03.036

subject

Has Abstract

pub_date

2008-04-15 00:00:00

pages

2599-603

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00310-7

journal_volume

18

pub_type

杂志文章

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