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Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents.

Abstract：

:The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zhao G,Miller MJ,Franzblau S,Wan B,Möllmann U

doi

10.1016/j.bmcl.2006.08.045

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

5534-7

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00930-9

journal_volume

16

pub_type

杂志文章

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