A concise synthesis and antimicrobial activities of 3-polyamino-23,24-bisnorcholanes as steroid-polyamine conjugates.

Abstract:

:A series of steroid-polyamine conjugates were synthesized and evaluated for their antimicrobial activity. This study was focused on the effect of stereochemistry at the C-3 and C-5 of steroids and types of polyamine at C-3 on activity against various human pathogens. All the conjugates exhibited strong antimicrobial activities against Gram-positive strains. Compound 18 was found to be the most potent in these series with a MIC value as low as 1 μg/mL against the bacterium Staphylococcus aureus ATCC6538P.

journal_name

Bioorg Med Chem Lett

authors

Kim HS,Khan SN,Jadhav JR,Jeong JW,Jung K,Kwak JH

doi

10.1016/j.bmcl.2011.05.048

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

3861-5

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00677-9

journal_volume

21

pub_type

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