A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids.

Abstract:

:The synthesis and biological activity of a novel series of tricyclic retinoic acid receptor antagonists are described. These compounds bind with high affinity to the RARs and are potent antagonists of retinoid function in in vitro and in vivo systems.

journal_name

Bioorg Med Chem Lett

authors

Vuligonda V,Standeven AM,Escobar M,Chandraratna RA

doi

10.1016/s0960-894x(99)00077-3

subject

Has Abstract

pub_date

1999-03-08 00:00:00

pages

743-8

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960894X99000773

journal_volume

9

pub_type

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