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Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide.

Abstract：

:Several unnatural derivatives of narciclasine were prepared in which the C-7 carbon was replaced with nitrogen. The 7-aza derivative and its N-oxide were prepared by the coupling of iodopicolinic acid with a conduramine unit derived chemoenzymatically from bromobenzene. Intramolecular Heck reaction was used to construct the isocarbostyryl ring system. The compounds were submitted to biological screening against cancer cell lines. Full experimental and spectra data are provided for all new compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vshyvenko S,Reisenauer MR,Rogelj S,Hudlicky T

doi

10.1016/j.bmcl.2014.07.034

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

4236-8

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00758-6

journal_volume

24

pub_type

杂志文章

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