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Structure based evolution of a novel series of positive modulators of the AMPA receptor.

Abstract：

:Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jamieson C,Maclean JK,Brown CI,Campbell RA,Gillen KJ,Gillespie J,Kazemier B,Kiczun M,Lamont Y,Lyons AJ,Moir EM,Morrow JA,Pantling J,Rankovic Z,Smith L

doi

10.1016/j.bmcl.2010.11.098

subject

Has Abstract

pub_date

2011-01-15 00:00:00

pages

805-11

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01723-3

journal_volume

21

pub_type

杂志文章

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