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Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.

Abstract：

:Piperazinyl benzamidines were prepared and found to bind to the rat delta (delta) opioid receptor. The most active compounds had a N,N-diethylcarboxamido group and a N-benzyl piperazine. The most potent among these was N,N-diethyl-4-[4-(phenylmethyl)-1-piperazinyl][2-(trifluoromethyl)phenyl]iminomethyl]benzamide (27) with a 1.22nM K(i) for the rat delta opioid receptor and ca. 1000 x selectivity relative to the mu opioid subtype.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nortey SO,Baxter EW,Codd EE,Zhang SP,Reitz AB

doi

10.1016/s0960-894x(01)00272-4

subject

Has Abstract

pub_date

2001-07-09 00:00:00

pages

1741-3

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960894X01002724

journal_volume

11

pub_type

杂志文章

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