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Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma.

Abstract：

:Multiple asthma-relevant cytokines including IL-4, IL-5, IL-13, and TSLP depend upon JAKs for signaling. JAK inhibition may, therefore, offer a novel intervention strategy for patients with disease refractory to current standards of care. Multiple systemically delivered JAK inhibitors have been approved for human use or are under clinical evaluation in autoimmune diseases such as rheumatoid arthritis. However, the on-target side effect profiles of these agents are likely not tolerable for many asthmatic patients. Limiting JAK inhibition to the lung is expected to improve therapeutic index relative to systemic inhibition. Thus, inhaled JAK inhibitors with lung-restricted exposure are of high interest as potential treatments for asthma.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Zak M,Dengler HS,Rajapaksa NS

doi

10.1016/j.bmcl.2019.126658

subject

Has Abstract

pub_date

2019-10-15 00:00:00

pages

126658

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30608-0

journal_volume

29

pub_type

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