Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines.

Abstract:

:The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.

journal_name

Bioorg Med Chem Lett

authors

Kojima N,Suga Y,Hayashi H,Yamori T,Yoshimitsu T,Tanaka T

doi

10.1016/j.bmcl.2011.08.011

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

5745-9

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01082-1

journal_volume

21

pub_type

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