Abstract:
:The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated γ-lactone fragment. It was revealed that the number of fluorine atoms on the γ-lactone moiety affects the growth inhibitory activities against human cancer cell lines.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Kojima N,Suga Y,Hayashi H,Yamori T,Yoshimitsu T,Tanaka Tdoi
10.1016/j.bmcl.2011.08.011subject
Has Abstractpub_date
2011-10-01 00:00:00pages
5745-9issue
19eissn
0960-894Xissn
1464-3405pii
S0960-894X(11)01082-1journal_volume
21pub_type
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