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Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

Abstract：

:We describe the synthesis and binding affinities on D(2), 5-HT(2A) and 5-HT(2C) receptors of 6-aminomethyl-6,7-dihydro-1H-indazol-4(5H)-ones and 6-aminomethyl-6,7-dihydro-3-methyl-benzo[d]isoxazol-4(5H)-ones, as conformationally constrained butyrophenone analogues. One of the new compounds showed good in vitro binding features, and a Meltzer's ratio characteristic of an atypical antipsychotic profile.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Barceló M,Raviña E,Masaguer CF,Domínguez E,Areias FM,Brea J,Loza MI

doi

10.1016/j.bmcl.2007.06.045

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

4873-7

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00725-1

journal_volume

17

pub_type

杂志文章

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