Abstract:
:Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while other variations were not. These results have important implications for drug development for schistosomiasis.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ronketti F,Ramana AV,Chao-Ming X,Pica-Mattoccia L,Cioli D,Todd MHdoi
10.1016/j.bmcl.2007.05.063subject
Has Abstractpub_date
2007-08-01 00:00:00pages
4154-7issue
15eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)00632-4journal_volume
17pub_type
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