Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Abstract:

:Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhanced inhibitory activity against Eg5 and induced mitotic arrest with characteristic monoastral spindles in HeLa cells.

journal_name

Bioorg Med Chem Lett

authors

Ogo N,Oishi S,Matsuno K,Sawada J,Fujii N,Asai A

doi

10.1016/j.bmcl.2007.04.101

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

3921-4

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00531-8

journal_volume

17

pub_type

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