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Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA.

Abstract：

:The T box transcription antitermination mechanism is found in many Gram-positive bacteria. The T box genes are typically tRNA synthetase, amino acid biosynthesis, and amino acid transport genes that have a common transcriptional control mechanism in which a unique RNA-RNA interaction occurs between an uncharged tRNA and the 5' leader region of the nascent mRNA, leading to antitermination of transcription. The tRNA binds the mRNA in at least two regions: the specifier sequence and the antiterminator. If the latter interaction does not occur, then transcription is terminated. The binding of eight different aminoglycosides to a model of the Bacillus subtilis tyrS T box antiterminator RNA has been studied using fluorescence resonance energy transfer. The observed single-site binding dissociation constants were in the low to mid micromolar range. The structure-activity relationship of aminoglycoside binding indicates that selective binding of small molecules to T box antiterminator RNA can be achieved.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Means JA,Hines JV

doi

10.1016/j.bmcl.2005.02.007

subject

Has Abstract

pub_date

2005-04-15 00:00:00

pages

2169-72

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00175-7

journal_volume

15

pub_type

杂志文章

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