Abstract:
:Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds 1 and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C(2) carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Lee HS,Lee TH,Yang SH,Shin HJ,Shin J,Oh KBdoi
10.1016/j.bmcl.2007.02.027subject
Has Abstractpub_date
2007-05-01 00:00:00pages
2483-6issue
9eissn
0960-894Xissn
1464-3405pii
S0960-894X(07)00222-3journal_volume
17pub_type
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