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New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3.

Abstract：

:We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Takeda Y,Yoshino T,Uoto K,Chiba J,Ishiyama T,Iwahana M,Jimbo T,Tanaka N,Terasawa H,Soga T

doi

10.1016/s0960-894x(02)00891-0

subject

Has Abstract

pub_date

2003-01-20 00:00:00

pages

185-90

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960894X02008910

journal_volume

13

pub_type

杂志文章

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