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Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives.

Abstract：

:In order to exploit cyclophilin as a potential target for neurological drug design, we demonstrate in this presentation that several nonimmunosuppressant analogues of cyclosporin A, modified at the various positions in the 'effector' domain, are equipotent nerve growth agents compared to cyclosporin A. Our results suggest that neurotrophic activity of cyclosporin A and its derivatives resides in the binding domain, and binding to cyclophilin and/or inhibiting rotamase activity may be a necessity for neurotrophic effects of cyclophilin ligands.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wei L,Steiner JP,Hamilton GS,Wu YQ

doi

10.1016/j.bmcl.2004.06.028

subject

Has Abstract

pub_date

2004-09-06 00:00:00

pages

4549-51

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960894X04007826

journal_volume

14

pub_type

杂志文章

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