5-Aminomethylquinoxaline-2,3-diones. Part I: A novel class of AMPA receptor antagonists.

Abstract:

:A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.

journal_name

Bioorg Med Chem Lett

authors

Auberson YP,Bischoff S,Moretti R,Schmutz M,Veenstra SJ

doi

10.1016/s0960-894x(97)10186-x

subject

Has Abstract

pub_date

1998-01-06 00:00:00

pages

65-70

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960894X9710186X

journal_volume

8

pub_type

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