Abstract:
:A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Auberson YP,Bischoff S,Moretti R,Schmutz M,Veenstra SJdoi
10.1016/s0960-894x(97)10186-xsubject
Has Abstractpub_date
1998-01-06 00:00:00pages
65-70issue
1eissn
0960-894Xissn
1464-3405pii
S0960894X9710186Xjournal_volume
8pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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