An approach for differentiating isozymes. Construction of libraries containing short aromatic peptides as part of a method to design selective inhibitors against lipases.

Abstract:

:Through synthesis and assays of peptidyl substrates, we could select substrates having peptidyl complementary against lipases. The best substrate showed 20-fold improved K(m) relative to non-peptidyl substrate. Using this information, we generated selective inhibitors. Lipase activities with peptidyl substrates were represented as fingerprints. Differences in fingerprints reflect different structures near active site of lipases, could be used for generating selective inhibitors.

journal_name

Bioorg Med Chem Lett

authors

Park S,Yu J

doi

10.1016/j.bmcl.2012.03.048

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

3147-51

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00369-1

journal_volume

22

pub_type

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