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Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.

Abstract：

:The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Horiuchi T,Chiba J,Uoto K,Soga T

doi

10.1016/j.bmcl.2008.11.090

subject

Has Abstract

pub_date

2009-01-15 00:00:00

pages

305-8

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01477-7

journal_volume

19

pub_type

杂志文章

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