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Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.

Abstract：

:Analogues of the tetrahydroisoquinoline family of antitumor antibiotics, 3-epi-jorumycin (3) and 3-epi-renieramycin G (4), in addition to their respective parent natural products (-)-jorumycin (1) and (-)-renieramycin G (2) were evaluated against both human colon (HCT-116) and human lung (A549) cancer cell lines. (-)-Jorumycin (1) displayed potent growth inhibition with GI50 values in the low nanomolar range (1.9-24.3 nM), while compounds 2-4 were found to be substantially less cytotoxic (GI50 0.6-14.0 microM).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lane JW,Estevez A,Mortara K,Callan O,Spencer JR,Williams RM

doi

10.1016/j.bmcl.2006.03.042

subject

Has Abstract

pub_date

2006-06-15 00:00:00

pages

3180-3

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00335-0

journal_volume

16

pub_type

杂志文章

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