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Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.

Abstract：

:The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wells G,Bradshaw TD,Diana P,Seaton A,Shi DF,Westwell AD,Stevens MF

doi

10.1016/s0960-894x(00)00027-5

subject

Has Abstract

pub_date

2000-03-06 00:00:00

pages

513-5

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00027-5

journal_volume

10

pub_type

杂志文章

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