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Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-l-aralkylpiperazines.

Abstract：

:The synthesis and in vitro Class III antiarrhythmic activity of several 4-aroyl (and aryl)-1-aralkylpiperazine and piperidine derivatives are described. Among several potent compounds identified in the series, RWJ-28810 (3), with its EC20 of 3 nM, ranks as one of the most potent (in vitro) compounds reported.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kanojia RM,Salata JJ,Kauffman J

doi

10.1016/s0960-894x(00)00581-3

subject

Has Abstract

pub_date

2000-12-18 00:00:00

pages

2819-23

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960894X00005813

journal_volume

10

pub_type

杂志文章

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