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Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.

Abstract：

:Introduction of 3-substituted azetidinyl substituents onto the 4,6-diaminopyrimidine scaffold allowed the improvement of PDE4 inhibiting activities. Preliminary in vivo activity in pulmonary inflammation models is reported.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Provins L,Christophe B,Danhaive P,Dulieu J,Gillard M,Quéré L,Stebbins K

doi

10.1016/j.bmcl.2007.03.047

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

3077-80

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00338-1

journal_volume

17

pub_type

杂志文章

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