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13C bis-labeled pyrroles: a tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester.

Abstract：

:Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly (13)C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Micheli F,Cavanni P,Di Fabio R,Donati D,Hamdan M,Provera S,Tranquillini ME,Vitulli G

doi

10.1016/j.bmcl.2006.11.039

subject

Has Abstract

pub_date

2007-02-15 00:00:00

pages

969-73

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)01332-1

journal_volume

17

pub_type

杂志文章

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