Abstract:
:New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac-Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Sasaki S,Hashimoto T,Obana N,Yasuda H,Uehara Y,Maeda Mdoi
10.1016/s0960-894x(98)00163-2subject
Has Abstractpub_date
1998-05-05 00:00:00pages
1019-22issue
9eissn
0960-894Xissn
1464-3405pii
S0960894X98001632journal_volume
8pub_type
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