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Design and synthesis of phosphotyrosine mimetics.

Abstract：

:Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial library based on a peptidomimetic beta-strand template.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yan Z,Kahn M,Qabar M,Urban J,Kim HO,Blaskovich MA

doi

10.1016/s0960-894x(03)00253-1

subject

Has Abstract

pub_date

2003-06-16 00:00:00

pages

2083-5

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960894X03002531

journal_volume

13

pub_type

杂志文章

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