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Synthesis and biological activity of macrocyclic taxane analogues.

Abstract：

:A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tarrant JG,Cook D,Fairchild C,Kadow JF,Long BH,Rose WC,Vyas D

doi

10.1016/j.bmcl.2004.02.086

subject

Has Abstract

pub_date

2004-05-17 00:00:00

pages

2555-8

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960894X04003026

journal_volume

14

pub_type

杂志文章

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