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Synthesis of nitrile derivatives of estrogens.

Abstract：

:The first time synthesis of 7alpha- and 11beta-nitrile estradiol is described. Reaction of 7alpha-cyano-19-nortestosterone with copper(II)bromide in acetonitrile at room temperature results in aromatization of the A-ring. Treatment of 11beta-cyano-19-nortestosterone-17-one under similar condition does not induce A-ring aromatization but rather results in bromination at the 2beta-position. However A-ring aromatized products are obtained when the latter compound is treated with Ac2O-Py-AcOCl, NBS and HCl.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ali H,van Lier JE

doi

10.1016/s0960-894x(02)00634-0

subject

Has Abstract

pub_date

2002-10-21 00:00:00

pages

2847-9

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960894X02006340

journal_volume

12

pub_type

杂志文章

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