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Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin.

Abstract：

:A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Antoszczak M,Maj E,Stefańska J,Wietrzyk J,Janczak J,Brzezinski B,Huczyński A

doi

10.1016/j.bmcl.2014.02.042

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

1724-9

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00174-7

journal_volume

24

pub_type

杂志文章

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