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Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid analogues.

Abstract：

:A series of flavonoid analogues were synthesized and screened for the in vitro antioxidant activity through their ability to quench 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical. The activity of these compounds, measured in comparison to the well-known standard antioxidants (29-32), their precursors (38-42) and other bioactive moieties (38-42) resembling partially the flavone skeleton was analyzed further to develop Quantitative Structure-Activity Relationship (QSAR) models using the Genetic Function Approximation (GFA) technique. Based on the essential structural requirements predicted by the QSAR models, some analogues were designed, synthesized and tested for activity. The predicted and experimental activities of these compounds were well correlated. Flavone analogue 20 was found to be the most potent antioxidant.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Das S,Mitra I,Batuta S,Niharul Alam M,Roy K,Begum NA

doi

10.1016/j.bmcl.2014.09.028

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

5050-4

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00953-6

journal_volume

24

pub_type

杂志文章

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