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Antimalarial activity of ferrocenyl chalcones.

Abstract：

:A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC(50) of 4.5 and 5.1 microM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wu X,Wilairat P,Go ML

doi

10.1016/s0960-894x(02)00430-4

subject

Has Abstract

pub_date

2002-09-02 00:00:00

pages

2299-302

issue

17

eissn

0960-894X

issn

1464-3405

pii

S0960894X02004304

journal_volume

12

pub_type

杂志文章

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