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Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives.

Abstract：

:A series of novel hybrid molecules 4a-y containing thiazole and benzotriazole templates were designed and synthesized. The structures of the synthesized compounds were elucidated by IR, (1)H NMR, (13)C NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity (zone of inhibition) against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Gaikwad ND,Patil SV,Bobade VD

doi

10.1016/j.bmcl.2012.03.094

subject

Has Abstract

pub_date

2012-05-15 00:00:00

pages

3449-54

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00424-6

journal_volume

22

pub_type

杂志文章

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