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A review on the chemical synthesis of pyrophosphate bonds in bioactive nucleoside diphosphate analogs.

Abstract：

:Currently, there is an ongoing interest in the synthesis of nucleoside diphosphate analogs as important regulators in catabolism/anabolism, and their potential applications as mechanistic probes and chemical tools for bioassays. However, the pyrophosphate bond formation step remains as the bottleneck. In this Digest, the chemical synthesis of the pyrophosphate bonds of representative bioactive nucleoside diphosphate analogs, i.e. phosphorus-modified analogs, nucleoside cyclic diphosphates, and nucleoside diphosphate conjugates, will be described.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Xu Z

doi

10.1016/j.bmcl.2015.06.094

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

3777-83

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00699-X

journal_volume

25

pub_type

杂志文章,评审

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