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Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules.

Abstract：

:A new class of chimeric molecules have been developed. These are based on polyphenols like catechin and epicatechin and monocyclic beta-lactams. The two units are joined via a triazole linker using the 'Click Chemistry' conditions. The compounds showed good to weak antibacterial activity against Escherichia coli as well as moderate inhibition of RNase A.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Roy B,Chakraborty A,Ghosh SK,Basak A

doi

10.1016/j.bmcl.2009.04.084

subject

Has Abstract

pub_date

2009-12-15 00:00:00

pages

7007-10

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00601-5

journal_volume

19

pub_type

杂志文章

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