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4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as potent anti-tumor agents.

Abstract：

:Based on the structure of 4-hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester (1), which exhibits selective cytotoxicity against a tumorigenic cell line, (2,4-dimethoxyphenyl)-(4-hydroxy-3-methyl-6-phenylbenzofuran-2-yl)-methanone (18m) was designed and synthesized as a biologically stable derivative containing no ester group. Although the potency of 18m was almost the same as our initial hit compound 1, 18m is expected to last longer in the human body as an anticancer agent.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hayakawa I,Shioya R,Agatsuma T,Furukawa H,Naruto S,Sugano Y

doi

10.1016/j.bmcl.2003.10.039

subject

Has Abstract

pub_date

2004-01-19 00:00:00

pages

455-8

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960894X03011284

journal_volume

14

pub_type

杂志文章

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