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Small molecule alteration of RNA sequence in cells and animals.

Abstract：

:RNA regulation and maintenance are critical for proper cell function. Small molecules that specifically alter RNA sequence would be exceptionally useful as probes of RNA structure and function or as potential therapeutics. Here, we demonstrate a photochemical approach for altering the trinucleotide expanded repeat causative of myotonic muscular dystrophy type 1 (DM1), r(CUG)exp. The small molecule, 2H-4-Ru, binds to r(CUG)exp and converts guanosine residues to 8-oxo-7,8-dihydroguanosine upon photochemical irradiation. We demonstrate targeted modification upon irradiation in cell culture and in Drosophila larvae provided a diet containing 2H-4-Ru. Our results highlight a general chemical biology approach for altering RNA sequence in vivo by using small molecules and photochemistry. Furthermore, these studies show that addition of 8-oxo-G lesions into RNA 3' untranslated regions does not affect its steady state levels.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Guan L,Luo Y,Ja WW,Disney MD

doi

10.1016/j.bmcl.2017.10.034

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2794-2796

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(17)31018-1

journal_volume

28

pub_type

杂志文章

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