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Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.

Abstract：

:A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Roy SS,Ghosh P,Sk UH,Chakraborty P,Biswas J,Mandal S,Bhattacharjee A,Bhattacharya S

doi

10.1016/j.bmcl.2010.09.127

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

6951-5

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01436-8

journal_volume

20

pub_type

杂志文章

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