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Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos.

Abstract：

:Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcepsilonRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcepsilonRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of gamma-chain subunit to suppress expression of FcepsilonRI among the three subunits.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Tamura S,Yoshihira K,Tokumaru M,Zisheng X,Murakami N

doi

10.1016/j.bmcl.2010.05.038

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

3872-5

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)00679-7

journal_volume

20

pub_type

杂志文章

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