Abstract:
:Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcepsilonRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcepsilonRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of gamma-chain subunit to suppress expression of FcepsilonRI among the three subunits.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Tamura S,Yoshihira K,Tokumaru M,Zisheng X,Murakami Ndoi
10.1016/j.bmcl.2010.05.038subject
Has Abstractpub_date
2010-07-01 00:00:00pages
3872-5issue
13eissn
0960-894Xissn
1464-3405pii
S0960-894X(10)00679-7journal_volume
20pub_type
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