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Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part II.

Abstract：

:A series of 5-(piperidinylethyloxy)quinoline 5-HT(1) receptor ligands have been studied by elaboration of the series of dual 5-HT(1)-SSRIs reported previously. These new compounds display a different in vitro pharmacological profile with potent affinity across the 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles and CNS penetration.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ward SE,Eddershaw P,Flynn ST,Gordon L,Lovell PJ,Moore SH,Scott CM,Smith PW,Thewlis KM,Wyman PA

doi

10.1016/j.bmcl.2008.11.052

subject

Has Abstract

pub_date

2009-01-15 00:00:00

pages

428-32

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01434-0

journal_volume

19

pub_type

杂志文章

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